In GBM cells, UPR aims are not limited to MMPs’ expression and secretion but also include GFs, chemokines, and inflammatory mediators, such as vascular endothelial growth factor A (VEGFA), ILs, and specifically IL-1β, IL-6, and IL-8, synchronizing an IRE1-induced attempt to augment pro-tumorigenic signaling (Figure 5) [205,206,207]. This evidence concerns the gene ERN1 and glioblastoma.