Hexokinase 2 (HK2), a well-established metabolic enzyme required for GBM aggressive properties, was found to be downregulated in XBP1-depleted cells, implying its role as the executioner of XBP1-dependent metabolism shift for ensuring GBM survival upon hypoxia in vitro and in vivo (Figure 2) [133]. Here, HK2 is linked to glioblastoma.