Bioinformatics analysis suggested that IRE1 is directly associated with MM survival and proliferation via its RIDD machinery targeting multiple mRNAs, among others cyclin-dependent kinase 12 (CDK12), DICER nuclease, and neurogenic locus notch homolog protein 1 (NOTCH1) (Figure 4) [163]. The gene discussed is ERN1; the disease is Miyoshi myopathy.