Likewise, high levels of s-XBP1 are responsible for the overexpression of MMP-1, MMP-3, and MMP-9 in oral and esophageal squamous cell carcinomas, respectively, while both ATF4 and ATF6 induce a disintegrin and metalloprotease 7 (ADAM7) expression and secretion in breast, ovarian, and prostate cancer [201,202,203]. This evidence concerns the gene ATF4 and esophageal squamous cell carcinoma.