ATRX was the most frequently altered DDR gene (10.1% overall), with mutations observed across 24 sarcoma subtypes (11 subtypes with >10% mutation rate including perivascular epithelioid cell tumor, uterine sarcoma other, angiosarcoma, leiomyosarcoma, mesenchymal chondrosarcoma, pleomorphic sarcoma, epithelioid sarcoma, sarcoma NOS, osteosarcoma, spindle cell sarcoma, and fibrosarcoma. Here, ATRX is linked to mesenchymal chondrosarcoma.