Karpinski et al. were able to show that updated risk groups by PSMA-PET/CT imaging, with predictors such as distant metastases, PSMA expression score, and total lesion count or total tumor volume, can be applied for more accurately predicting the 3- and 5-year overall survival probabilities of prostate cancer than the conventional risk groups [35]. This evidence concerns the gene FOLH1 and Familial prostate cancer.