The common genetic abnormalities of AML are the following: translocation between chromosomes 15 and 17 (PML-RARA in APL), translocation between chromosomes 8 and 21 (RUNX1-RUNX1T1), FLT3-ITD, NPM1, CCAAT Enhancer Binding Protein Alpha (CEBPA) mutations, the inversion of chromosome 16, and KMT2A rearrangement [176]. The gene discussed is CEBPA; the disease is acute promyelocytic leukemia.