Known genetic alterations in B-ALL are hyperdiploidy or hypodiploidy, t(12;21) or ETV-RUNX1 fusion gene, t(9;22) or lysine-specific methyltransferase 2A (KMT2A) gene rearrangements, IKZF1 deletion or intrachromosomal amplification of chromosome 21 (iAMP21) or t(1;19) TCF3-PBX1 fusion gene. Here, KMT2A is linked to acute lymphoblastic leukemia.