TNF and neoplasm: Additionally, CM from PNF cells (ipNF95.6) elevated IL-6 secretion in both THP1 monocytes (p = 0.0011) and macrophages (p = 0.0006), and CM from NF1-mutant non-tumor Schwann cells (ipnNF95.11c, p = 0.0196) and PNF cells (ipNF95.11bC, p = 0.0026; ipNF95.6, p = 0.0431) induced TNFα secretion in THP1 macrophages compared to non-CM-treated groups (Figure 6A).