Specifically, the IHC staining showed the ability of MSU-42011 to reduce the expression of CD206 and FOXP3 (Figure 2D), and this was confirmed by flow cytometry, which showed that MSU-42011 reduced tumor-promoting macrophages (low CD206 and CD163), FOXP3+ Treg, and increased the presence of activated CD8+ T cells in the flank tumors of MPNST (Figure 2E). This evidence concerns the gene MRC1 and malignant peripheral nerve sheath tumor.