RAS Pathway Alterations: KRAS, NRAS, and BRAF mutations are reported in roughly 10-20% of PBL cases, with considerable overlaps in pathway activation with MM [11,12,13,14,15,16,17,18,19,32,33,34,35,36,37,38,39,40,41,42]. The gene discussed is BRAF; the disease is Miyoshi myopathy.