Key points of differentiation have concentrated on the prevalence and processes of particular gene mutations (for example, MYC, STAT3, PRDM1, and TP53 in PBL; KRAS, NRAS, BRAF, and TP53 in MM; EZH2, BCL2, and BCL6 in DLBCL), as well as unique structural rearrangements (Table 2: genetic differences and Table 3: epigenetic differences). This evidence concerns the gene NRAS and diffuse large B-cell lymphoma.