TP53 and ovarian carcinoma: Concomitant with this, our Western blot analysis further confirmed that p14ARF and critical p53 targets, such as p21, Noxa, and Puma, were significantly increased in OVCAR-8, suggesting the activation of p53 in ovarian cancer cells treated with vector-based or IVT-mRNA-delivered ΔDAPK1 (Figure 10B).