PNI varied by TLS presence and subtype.TLS -ve Luminal B breast cancer: PNI more frequent in elderly and postmenopausal women; significantly associated with LVITLS +ve Luminal B breast cancer: no PNI correlationLuminal B-HER2: PNI only in TLS -ve tumorsTNBC-TLS +ve: PNI correlated with recurrenceTNBC-TLS -ve: PNI strongly associated with high grade and recurrence. The gene discussed is ERBB2; the disease is Tumor Lysis Syndrome.