There has been research revealing that frizzled homolog 10 (FZD10), a Wnt signaling receptor, is overexpressed in a majority of synovial sarcomas while absent in most normal tissues, which justifies the clinical trial of a radiolabeled monoclonal antibody against FZD10 (NCT01469975), though less toxic radioisotopes might be a better option as stated by the results report [33]. The gene discussed is FZD10; the disease is synovial sarcoma.