TFE3 and neoplasm: Tanaka and colleagues discovered in their ASPSCR1–TFE3-driven mouse model that a transcriptional target of the hallmark gene fusion ASPSCR1–TFE3, GPNMB (which encodes glycoprotein nmb), was highly expressed to facilitate tumor invasion and migration; while silencing GPNMB could inhibit these malignant characteristics [46], supporting the idea that GPNMB may be a druggable target.