Molecular analyses have discovered that the oncoproteins PAX3–FOXO1 and PAX7–FOXO1, produced by chromosomal translocations t(2;13)(q36;q14) and t(1;13)(p36;q14), respectively, are the most common mechanisms that drive the oncogenesis of ARMS [37]. Here, PAX3 is linked to alveolar rhabdomyosarcoma.