Our findings corroborate earlier research indicating that OMP, used as a reference drug, significantly diminished the levels of HMGB1, NF-κB p65, and NLRP3 in comparison to the ulcer group [75] and substantially reduced the levels of IL-1β, IL-6, and TNF-α in gastric mucosa [76]. The gene discussed is HMGB1; the disease is ulcer disease.