In another study, the high-affinity monoclonal antibody RDM028 targeting the α3 domains of MICA and MICB was also reported to have inhibitory effects on the exfoliation of MICA and MICB, enhance the anti-tumor activity of NK cells, and promote the interaction between MICA/B and NKG2D [100]. This evidence concerns the gene KLRK1 and neoplasm.