Huang et al. pointed out that the expression of HIF-1α can promote the epithelial–mesenchymal transition (EMT) of gastric cancer cells, while dextran sulfate (DS) can inhibit HIF-1α and reduce the expression of other molecules closely related to HIF-1α, including MMP2 and TGF-β. Here, TGFB1 is linked to gastric cancer.