miR-153 is lowly expressed in pancreatic cancer cells and is insufficient for the inhibition of the expression of HIF-1α, leading to increased HIF-1α expression and the induction of ADAM10 expression, resulting in an increase in sMICA and hindering the activation of NK cells, causing the internalization of NKG2D receptors and preventing NK cells from effectively controlling tumor metastasis [58]. Here, HIF1A is linked to pancreatic neoplasm.