HIF1A and gastric cancer: Han et al. discovered a small molecule compound that can inhibit the expression of CD147 in gastric cancer cells, reduce the activation of the MAPK signaling pathway mediated by CD147, and arrest the cell cycle of gastric cancer cells at G2/M, leading to the inactivation of the PI3K/AKT/mTOR signaling pathway and subsequently inhibiting the downstream HIF-1α/VEGF signaling pathway and HIF-1α/MMP signaling pathway, thereby delaying the progression of gastric cancer [84].