In addition to the benefits of exercise-induced IL-6, such as promoting OCN secretion and fatty acid oxidation, it also exacerbates local and systemic osteoclast-mediated bone destruction, including Paget’s disease of bone (PDB), rheumatoid arthritis (RA), and the bone metastasis of breast cancer [84,85,86]. The gene discussed is BGLAP; the disease is rheumatoid arthritis.