Also, our laboratory has shown enhanced maintained [Ca2+]c and contraction induced by Ang II, KCl, and BAY K-8644 in renal arterial VSMCs from a rat model of placental ischemia, suggesting enhanced Ca2+ entry mechanisms in small renal arteries as a major factor in the increased renal arterial resistance during HTN-Preg [370]. This evidence concerns the gene AGT and hypertensive disorder.