Also, Piezo1 expression and [Ca2+]c are increased in PASMCs [374] and pulmonary arterial ECs from idiopathic PAH patients and in the pulmonary artery and PASMCs from animal models of severe PAH, suggesting that excessive Ca2+ entry through mechanosensitive stretch-activated channels plays a critical role in PAH-related increases in pulmonary vasoconstriction and remodeling [375]. Here, PIEZO1 is linked to pulmonary arterial hypertension.