Also, chronic Ang II infusion in rats augments coronary arterial RhoA/ROCK activity, tunica media thickness, and perivascular fibrosis, and ROCK inhibitors attenuate Ang II-induced coronary hypertrophy/fibrosis [348], superoxide anion production [348], and monocyte chemoattractant protein-1 and PAI-1 levels [349,350]. Here, AGT is linked to cardiac hypertrophy.