Probiotics, combinations particularly Lactobacillus and Bifidobacterium, have been revealed to be effective in controlling dyslipidaemia and obesity in breast cancer patients; as found in a comprehensive review and meta-analysis of clinical trials, they reduce pro-inflammatory markers such as TNF-α, later improving the quality of life in those who are identified with breast cancer-associated lymphedema [189]. This evidence concerns the gene TNF and breast carcinoma.