The likely association of SLC4A11 with normal cytoskeleton formation in the corneal endothelium is also suggested by the abnormal morphology of endothelial cells found in histologic examination of corneal endothelium from patients with CHED, and the presence of multinucleated cells [89]. This evidence concerns the gene SLC4A11 and congenital hereditary endothelial dystrophy of cornea.