Given the involvement of SLC4A11 in oxidative stress, the observed decrease in NRF2 expression in the corneal endothelium of CHED patients may be explained by oxidative stress resulting from impaired or complete loss of SLC4A11 function caused by mutations in the corresponding gene [83]. The gene discussed is SLC4A11; the disease is congenital hereditary endothelial dystrophy of cornea.