Another study evaluated the correlation between SOST levels and the risk of cardiovascular disease in patients with type 2 diabetes mellitus; ultimately, they concluded that SOST may play a protective role against the development of atherosclerosis in patients with T2D by decreasing calcium deposition, decreasing the proliferative and inflammatory response, and promoting the cellular survival of the VSMC under calcified conditions [45]. This evidence concerns the gene SOST and atherosclerosis.