SOST and chronic obstructive pulmonary disease: In COPD, bronchial epithelial pathology activates the Wnt pathway, and SOST can block the Wnt signaling pathway; therefore, Amado [47] and others further investigated the link between SOST levels and COPD patients’ conditions, confirming that SOST levels correlate with body composition and lung function in COPD patients, and that lower levels of SOST predicted a higher risk of deterioration and hospitalization.