Subgroup analyses revealed that MMP-10 was significantly correlated with 2-year MACE in PAD patients with diabetes (adjusted HR: 1.18, 95% CI: 1.13–1.53, p = 0.019), whereas MMP-7 was significantly associated with 2-year MACE among female PAD patients (adjusted HR: 1.31, 95% CI: 1.15–1.69, p = 0.009). This evidence concerns the gene MMP7 and peripheral arterial disease.