Furthermore, Khatib emphasized the indispensable role of GPX8 in maintaining an aggressive breast cancer phenotype, while Nguyen discovered that GPX8 is involved in renal cell carcinoma tumorigenesis, indicating that GPX8 could serve as a novel prognostic factor, therapeutic target, and marker of EMT across various cancer subtypes [51,52,53]. The gene discussed is GPX8; the disease is hereditary clear cell renal cell carcinoma.