Their study explored the Cdkn2a/Cdkn2b gene locus in osteosarcomagenesis, finding that MSCs lacking p15Ink4b, p16Ink4a, or p19Arf transform faster than wild-type MSCs, suggesting that cell cycle dysregulation is key to osteosarcoma initiation. The gene discussed is CDKN2A; the disease is osteosarcoma.