Collagen I, secreted by cancer-associated fibroblasts (CAFs), activates DDR1 on pancreatic cancer cells, enhancing macropinocytosis and mitochondrial biogenesis via the DDR1-NF-κB-NRF2 axis, and accelerating cell proliferation in vitro and tumor growth in vivo [26]. This evidence concerns the gene NFKB1 and pancreatic neoplasm.