Amongst the differentially expressed genes were several known mediators of cartilage matrix remodelling and inflammatory responses including the upregulation of ANGPTL7 (FC = +3.0), CTRHC1 (FC = + 1.7), CXCL6 (FC = +3.9), CXCL1 (FC = +1.6), CXCL3 (FC = + 1.5), MMP7 (FC = +2.6), DUSP4 (FC = +2.5), ITGA5 (FC = +2.0), and OMD (osteomodulin; FC = +2.7), and downregulation of HAS3 (Hyaluronan Synthase 3; FC = −2.9), ADAMTS12 (FC = −1.5), ADAMTS14 (FC = −2.1), FGF9 (FC = −2.4), which regulates chondrogenesis, and HS3ST1 (FC = −2.7), a glycosaminoglycan which modulates matrix integrity (Figure 2E). Here, ITGA5 is linked to occult macular dystrophy.