As expected, these common genes included many of the genes previously identified as differentially expressed upon SFEV treatment of chondrocytes, e.g., the upregulation of OMD, ANGPTL7, CTHRC1, CXCL1, CXCL3, DUSP4 and ITGA5, and the downregulation of HAS3, ADAMTS12, ADAMTS14, FGF9, HS3ST1, SEMA3ANGF, and PTGS2. Here, CXCL1 is linked to occult macular dystrophy.