As expected, these common genes included many of the genes previously identified as differentially expressed upon SFEV treatment of chondrocytes, e.g., the upregulation of OMD, ANGPTL7, CTHRC1, CXCL1, CXCL3, DUSP4 and ITGA5, and the downregulation of HAS3, ADAMTS12, ADAMTS14, FGF9, HS3ST1, SEMA3ANGF, and PTGS2. This evidence concerns the gene HAS3 and occult macular dystrophy.