CASP1 and Alzheimer disease: Keratin 14-specific IL-33 overexpressing transgenic (IL-33Tg) mice: the mice develop skin-specific IL-33-induced acute-phase dermatitis with symptoms similar to human AD, keratin 14-specific IL-18 overexpressing transgenic (IL-18Tg) mice: models of chronic-phase AD, keratin 14-specific caspase-1 overexpression transgenic (KCASP1Tg) mice, which are regarded as a model that combines features of both AD and psoriasis [24].