BCL2 and neoplasm: Mechanistic studies revealed that its anti-tumor effects involved the regulation of multiple pathways, as follows: induction of apoptosis through the modulation of apoptosis-related proteins (e.g., Bcl-2/Bax) and activation of the caspase cascade; triggering ferroptosis by increasing intracellular ROS and lipid ROS levels while reducing GSH content; and attenuating cell migration by inhibiting FAK phosphorylation.