The reduction in H4K8la induced by Bromodomain-containing protein 4 (BRD4) silencing exacerbates the A1 polarization of astrocytes and increases neuroinflammation and neuronal death, ultimately impairing the recovery and prognosis of neurological function in mice after subarachnoid hemorrhage [97]. Here, BRD4 is linked to subarachnoid hemorrhage.