TTK and pancreatic ductal adenocarcinoma: In pancreatic ductal adenocarcinoma (PDAC), the establishment of a glycolytic positive feedback loop is mechanistically dependent on the specific enrichment of H3K18la at the promoter regions of TTK protein kinase (TTK) and BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) genes, which subsequently activates their transcriptional activity and promotes PDAC progression [46].