Although the prevalence of asthma did not differ among the identified AATD genotypes, the authors found a higher prevalence of bronchial hyperresponsiveness in PI*MZ subjects compared to other deficient genotypes, as well as increased bronchial hyperresponsiveness in children with AAT levels below 116 mg/dL. The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.