HAVCR1 and acute kidney injury: In a murine model of acute kidney injury (AKI) induced by ischemia–reperfusion injury (IRI), single-nucleus RNA sequencing analysis demonstrated that failed-repair proximal tubular cells (FR-PTCs) are marked by a downregulation of genes associated with normal differentiation and proliferation, such as Hnf4a, alongside an upregulation of genes related to injury, including Havcr1, Krt20, Ccl2, and Vcam1.