Researchers have detected the activation of Casp3 and the cleavage of the GSDME protein in a mouse UUO-induced renal fibrosis model, and knockout of GSDME or Casp3 inhibited tubular cell pyroptosis, thereby alleviating hydronephrosis, interstitial fibrosis, and inflammatory cell infiltration [60]. Here, GSDME is linked to renal fibrosis.