When compared to the positive control, which consisted of PEI 25 K/p53 complexes, these MB-NSi-p53-CS ternary complexes exhibited a markedly superior capacity for delivering the p53 gene into tumor cells, which led to the expression level of p53 mRNA in tumor cells containing mutp53 increases of approximately 1.5-fold. The gene discussed is TP53; the disease is neoplasm.