TP53 and neoplasm: To enhance zinc affinity for a more precise Zn2+ release in the tumor microenvironment (TME) and improve p53 reactivation capabilities, optimized chemical structures yielded related compounds, ZMC2 and ZMC3, two other thiosemicarbazones, which deliver Zn2+ more efficiently and also restore p53(R175H)’s wild-type conformation [48].