Additionally, Yu et al. found the TIM3/CEACAM1 (Carcinoembryonic antigen cell adhesion molecule 1) pathway, which is involved in immune checkpoints, correlated with CD8+ T cell exhaustion in MDS, and which activates the NF-κB/NLRP3/Caspase-1 pathway in MDSCs, leading to the expression of IL-1β/18 [61]. The gene discussed is HAVCR2; the disease is myelodysplastic syndrome.