In addition, haploinsufficiency of del(5q) genes with Tp53 loss can induce AML in murine models; and the loss of 5q with TP53 mutations promotes the structural and karyotypic abnormalities in isogenic MDS induced pluripotent stem cells (iPSC) by perturbing genome stability [218,219]. This evidence concerns the gene TP53 and myelodysplastic syndrome.