The poor T cell infiltration (reason for poor response to immunotherapy) in PCa [84,85] is due to a hypoxic environment [86] causing an acidic pH [87], the depletion of essential nutrients, the increased expression of adenosine and PD-L1 [88], and the increased expression of immunosuppressive transforming growth factor (TFG)-β. This evidence concerns the gene CD274 and posterior cortical atrophy.