LAG3 and posterior cortical atrophy: Tregs contribute to the growth, migration, and invasion of PCa via the increased secretion of IL-10, TGF-β, and IL-35, leading to the suppression of immune response, T cells’ exhaustion, and the increased expression of neoantigens such as lymphocyte activation gene-3 (LAG3), T-cell immunoglobulin and mucin domain 3 (TIM3), PD-1, and PD-L1 (Figure 3).