In addition to hypermethylation, post-transcriptional histone modifications involving histone deacetylases (HDACs, e.g., HDAC1), histone methyltransferases (HMTs, e.g., EZH2), and histone demethylases (HDMs, e.g., LSD1) also play a critical role in PCa. This evidence concerns the gene EZH2 and posterior cortical atrophy.