IL-6 secreted by TME cells activates Janus kinase-signal transducer and activator of transcription (JAK/STAT), extracellular signal-regulated kinase (ERK)1/2-mitogen activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K) pathways, and contributes to cell proliferation, EMT, tumor migration, increasing its growth and aggressiveness, and resistance to chemotherapy by inducing anti-apoptotic pathways. This evidence concerns the gene IL6 and neoplasm.