Compared with the SHAM group, Mfn2 protein expression was significantly upregulated in the HF group (p < 0.01); compared with the HF group, Mfn2 protein expression was significantly downregulated in the HE and HP groups, as well as in the HEP group (p < 0.01). The gene discussed is MFN2; the disease is hereditary elliptocytosis.