OPA1 protein expression was significantly downregulated in the HF group compared with the SHAM group (p < 0.01); OPA1 protein expression was significantly upregulated in the HE group, as well as in the HEP group, compared with the HF group (p < 0.05), and OPA1 protein expression was upregulated in the HP group. The gene discussed is OPA1; the disease is hydrops fetalis.