These genes span key functional categories, including glutathione synthesis (as Gclc), mitochondrial detoxification (as Gpx6), redox cycling (as NQO1), selenium transport (as SEPP1), immune signaling (as CCL5), and DNA recombination (as Rag2), underscoring the multifaceted disruption of redox regulation in the MetS kidney. The gene discussed is GPX6; the disease is metabolic syndrome.