VEGFA and brain ischemia: In conditions of acute brain ischemia, Angiolin exhibits pronounced endothelial-protective properties—it maintains endothelial cell density, increases RNA concentration in cell nuclei, boosts the density of proliferating endothelial cells (BrdU test), enhances the utilization of endogenous L-arginine, and increases the expression of vascular endothelial growth factor (VEGF) and eNOS.