In the myocardium of rats exposed to prenatal hypoxia, we recorded elevated levels of the endothelial dysfunction marker sEPCR, along with decreased levels of Tie-2 and VEGF-B, which serve protective roles, as well as a notable antioxidant deficiency (manifested as reduced Cu/ZnSOD and GPX) [253]. The gene discussed is TEK; the disease is endothelial dysfunction.