PANK1 and neurodegeneration with brain iron accumulation 5: Our results in fibroblasts derived from the EE patient clearly showed that lipofuscin granules are formed in mitochondria in a similar way as other pathologies such as pantothenate-kinase-associated neurodegeneration (PKAN) and beta-propeller protein-associated neurodegeneration (BPAN) [28,79,80].