PLA2G6 and neurodegenerative disease: PLAN is a rare genetic neurodegenerative disease within the group of Neurodegeneration with Brain Iron Accumulation (NBIA) disorders, caused by mutations in the PLA2G6 gene that encodes the calcium-independent Phospholipase A2 group VI (iPLA2β), an enzyme responsible for the scission of peroxidised fatty acids in the sn2-position of membrane glycerophospholipids [57,58].