Consistent with the cellular experiment results, oral HIC, CFS, and Arg reduced the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in the serum and colon of UC mice while upregulating the levels of occludin and ZO-1 in colonic tissues. The gene discussed is OCLN; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.