For instance, the SOD mimetic EUK-134, when combined with chemotherapeutic agents, induces synergistic apoptosis in pancreatic cancer cells, while GPx4-specific inhibitors, such as RSL3, trigger ferroptosis and exhibit potentiated anti-tumor effects when paired with sorafenib in hepatocellular carcinoma and other solid malignancies [339,340,341]. This evidence concerns the gene SOD1 and neoplasm.