Studies have demonstrated that TANs may promote tumor angiogenesis by inducing sustained release of vascular endothelial growth factor (VEGF) from peripheral endothelial cells or by secreting pro-inflammatory and immunosuppressive factors, such as IL-1β, IL-17, TNF-α, CCL4, MMP-9, CXCL8, and ANG1 [149]. The gene discussed is TNF; the disease is neoplasm.