NFE2L2 and neoplasm: Whereas FoxP3 functions as a tumor suppressor with FoxP3+ Tregs, exhibiting protective effects [170], and has been demonstrated to eliminate macrophages and monocytes while inhibiting their protumor activities [171], follistatin (FST) serves to inhibit the production of ROS with FST transcription initiation facilitated by Nrf2 [172].