In addition, Xin et al. [184] showed that a complex formed by three components—hawthorn polyphenols, D-chiro-inositol (DCI), and EGCG—had synergistic hypoglycemic effects mediated by PI3K/AKT/GSK-3 in the liver of induced diabetic mice, subsequently relieving insulin resistance. Here, AKT1 is linked to Insulin resistance.