In contrast, PD patients under 65 years (Figure 4B; Supplementary Table S9) exhibited a more interconnected RAS network, with AT1-AAs significantly associated with AT2-AAs (rs = 0.593, p < 0.001) and MasR-AAs (rs = 0.473, p = 0.006), and MasR-AAs significantly associated with ACE2-AAs (rs = 0.427, p = 0.015). Here, AGTR2 is linked to Parkinson disease.