Increased hemoglobin values favor myocyte oxygenation, while Klotho preservation prevents the negative consequences of Klotho deficiency, which reproduces the cardiovascular phenotype of CKD: cardiovascular calcification, hyperaldosteronism, left ventricular hypertrophy, and myocardial fibrosis [41,42,43,44,45]. This evidence concerns the gene KL and Myocardial fibrosis.