CEP290 and bacterial infectious disease: PoC3 in the serum of Japanese flounder has the ability to bind to a variety of bacteria (e.g., Pseudomonas fluorescens, Vibrio anguillarum, Edwardsiella tarda, Vibrio harveyi, Streptococcus iniae, and Escherichia coli), and rPoC3a mediated increased resistance against bacterial infection [60].