Lycopene is present in tomatoes and tomato products and has anti-cancer properties as an antioxidant [177].(1)Lycopene has been shown to inhibit prostate cancer cell progression and proliferation, induce cell cycle arrest, and promote apoptosis [178].(2)Lycopene suppresses smoking-induced lung cancer by activating base excision repair [179].(3)It inhibits gastric cancer growth without impacting epithelial cells [180].(4)It inhibits liver cancer metastasis by downregulating NADPH oxidase 4 expression [181]. The gene discussed is NOX4; the disease is liver cancer.