CASP12 and brain ischemia: In cerebral ischemia, the synergistic action of GSH and GPX7 exerts a protective effect through the following mechanisms: GPX7 catalyses the reduction of peroxides, thereby preventing ROS accumulation-induced ERS and UPR [42]; at the same time, GPX7 inhibits ERS-associated apoptotic signals (e.g., CHOP, caspase-12) via a GSH-dependent pathway [43], thereby protecting neuronal survival.