In terms of molecular function (MF), the hub genes exhibited antioxidant activity, NADH dehydrogenase activity and tumour necrosis factor receptor binding (Figure 5A–C), and KEGG pathway analysis further revealed that the hub genes were significantly enriched in the primary immunodeficiency, oxidative phosphorylation and T cell receptor signalling pathways (Figure 5D). The gene discussed is ENSG00000251605; the disease is inborn error of immunity.