In patients with compensated cirrhosis, elevated CRP ≥ 5 mg/L was strongly linked to a significant reduction in M-HDL (p = 0.038), S-HDL (p < 0.001), and XS-HDL (p = 0.013) subclass concentrations, while L-HDL (p = 0.052) concentrations showed only a non-significant trend. The gene discussed is CRP; the disease is Cirrhosis.