Among NOTCH alterations, NOTCH1 mutations have been linked to an increase in MHC class I expression and T-cell infiltration, two features that may sensitize NSCLC patients to ICIs, corroborating the idea that specific NOTCH mutations could serve as independent predictive biomarkers in the prognosis of NSCLC patients treated with ICIs [209]. The gene discussed is NOTCH1; the disease is non-small cell lung carcinoma.