Our group demonstrated that the downregulation of miR-27 family (miR-27a and miR-27b) and the upregulation of miR-200 family (miR-200a), could significantly modulate NRF2-KEAP1 activity in NSCLC and SCLC cell lines panels, as well as in a training set of 29 tumors and adjacent normal tissues from NSCLC patients [99]. This evidence concerns the gene KEAP1 and small cell lung carcinoma.