NOTCH1 has been much more associated with stem-like characteristics and self-renewal capacity of NSCLC cells; NOTCH2 in mitogen-activated protein kinase (MAPK) pathways with growth and development of NSCLC; NOTCH3 has been linked to TGF-β-mediated EMT processes via transcriptional repression of Zinc finger E-box binding protein 1 (ZEB1), NOTCH4 has also been associated with anti-tumor immunity, promoting the infiltration of diverse immune cells populations [129]. The gene discussed is NOTCH3; the disease is neoplasm.