NFE2L2 and non-small cell lung carcinoma: On the epigenetic front, in molecularly stratified subpopulations of NSCLC, particularly in LUAD and LUSC cases lacking KRAS mutations, our group demonstrated a strong positive correlation has been observed between KEAP1 promoter hypermethylation and elevated NRF2 mRNA expression, along with increased expression of multiple ARE-driven target genes.