Notably, NRF2 hyperactivation in NSCLC is also linked to hypoxia-inducible factor 1α (HIF1α), further amplifying glycolytic activity by enhancing the expression of several key genes including hexokinase 2 (HK2), phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3), pyruvate kinase isozymes M2 (PKM2) and lactate dehydrogenase A (LDHA) [185]. Here, HK2 is linked to non-small cell lung carcinoma.