Curcumin modulates the expression of several cancer targets, including cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), STAT-3, tumor necrosis factor-α (TNF-α), and cyclin D1 and is found to decelerate cell growth through cell death and cycle arrest [38,59]. The gene discussed is NFKB1; the disease is cancer.