Inflammation and OS facilitate cancer development in multi-phase which includes direct injury to nuclear DNA and modification of intracellular signaling pathways involved in inflammation such as protein kinase C (PKC), protein kinase b (PKB), tyrosine kinases, phosphoinositide 3-kinase (PI3K), MAPKs, glycogen synthase kinase, etc. These signaling pathways also trigger redox-related transcription factors such as Nrf2, NF-κB, or AP-1 [79]. Here, NFE2L2 is linked to cancer.