The very low volume of this pathology within SNc dopamine neuron soma suggests that disSOD1 deposition may instead occur in axons or dendrites, or may arise in alternative cell types such as oligodendrocytes or microglia, as observed in transgenic mutant SOD1 mice [62] and ALS patients [34]warranting further investigation. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.