We found that the signaling of VEGFA-VEGFR1, VEGFA-VEGFR2, MIF-(CD74 + CXCR4) and MIF-(CD74 + CD44) was significantly increased in the high-risk state; whereas the signaling of LGALS9-CD45, LGALS9-CD44, and IL1B-IL1R2 was decreased, which may affect the tumor cell adhesion and migration. The gene discussed is CD44; the disease is neoplasm.