Noticeably, various innate immunity, immunity and inflammatory response processes were up-regulated primarily in tumors of the Group-2 (TSPY-6wk) mice but not those for the Group-1 (EGFP-6wk) nor the Group-5 (TSPY-9wk) mice (Fig. 2B, right, green labels), suggesting that significant immune and inflammatory responses were present in the tumor microenvironment in Group-2 mice with TSPY expression at early stage of the hepatic oncogenesis. The gene discussed is TSPY1; the disease is neoplasm.