In breast cancer, NF-κB activation via RANK- or PAK5 (P21cdc42/rac1-activated kinase 5)-mediated phosphorylation of RelA enhances cyclin D1 expression by facilitating NF-κB nuclear translocation and binding to the cyclin D1 promoter, thereby accelerating cell cycle progression [240–242]. This evidence concerns the gene NFKB1 and breast cancer.