CRIP1 and pancreatic ductal adenocarcinoma: In pancreatic ductal adenocarcinoma, NF-κB is activated by the pro-oncogenic protein cysteine-rich intestinal protein 1 (CRIP1), which results in the transcriptional induction of the chemokines CXCL1 and CXCL5 and the recruitment of MDSCs to promote immunosuppression [304].