NFKB1 and systemic lupus erythematosus: Genetic variants in several key components of the TLR/NF-κB signaling axis have been identified in association with lupus nephritis, the leading cause of morbidity and mortality in SLE; these include TLR3, TLR7, TLR9, MYD88, IRAK1, Peli1, and TNFAIP3 [219, 220].