CXCL12 and head and neck squamous cell carcinoma: NF-κB also mediates tumor cell expression of chemokines, such as CXCL12, which recruit NK cells, as shown in a head and neck squamous cell carcinoma (HNSCC) model where CHMP2A (chromatin-modifying protein/charged multivesicular body protein) ablation activates NF-κB and amplifies chemokine secretion [317].