NFKB1 and cancer: In TAMs, canonical NF-κB (RelA/p50) promotes proinflammatory cytokine production (e.g., TNF-α, IL-6) in inflammation-driven cancers (e.g., colitis-associated colon cancer) or immunosuppressive IL-10 secretion in breast and ovarian cancers, fostering tumor growth and immune escape [174, 384–386].