Prolonged NF-κB signaling contributes to the pathogenesis of a variety of inflammatory and autoimmune diseases, such as rheumatoid arthritis (RA) [30], inflammatory bowel disease (IBD) [31, 32], systemic lupus erythematosus (SLE) [33], atherosclerosis [34], neurodegenerative diseases [35], and chronic obstructive pulmonary disease (COPD) [36]. The gene discussed is NFKB1; the disease is rheumatoid arthritis.