In breast cancer, NF-κB activation via RANK- or PAK5 (P21cdc42/rac1-activated kinase 5)-mediated phosphorylation of RelA enhances cyclin D1 expression by facilitating NF-κB nuclear translocation and binding to the cyclin D1 promoter, thereby accelerating cell cycle progression [240–242]. The gene discussed is CCND1; the disease is breast cancer.