SE(Trojan-TLR7/8a) evoked broad and prolonged immunity against multiple influenza (H1N1, H5N2, H7N3, H9N2, and H3N2) and SARS-CoV-2 variants (Alpha, Beta, Wuhan, Delta, and Omicron BA.2) by activating GC B cells and polyfunctional T cells, leading to 100% protection and full body weight recovery postimmunization. This evidence concerns the gene TLR7 and influenza.